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目的观察前列地尔辅助介入术治疗不稳定型心绞痛对患者血清Hcy、SOD及IL-23水平的影响。方法将不稳定型心绞痛患者212例随机分为研究组和对照组各106例,研究组采用前列地尔辅助介入术治疗,对照组采用阿托伐他汀辅助介入术治疗,2组均分别于治疗前后检测血清Hcy、SOD及IL-23水平。结果治疗后2组血清Hcy、IL-23水平均降低于治疗前,SOD水平均高于治疗前,且研究组变化幅度均大于对照组,差异均有统计学意义(P<0.05)。结论前列地尔较阿托伐他汀辅助介入术治疗不稳定型心绞痛能更有效地降低血清Hcy、IL-23水平和升高血清SOD水平。
Objective To observe the effect of alprostadil interventional treatment on serum Hcy, SOD and IL-23 in patients with unstable angina pectoris. Methods Two hundred and twelve patients with unstable angina were randomly divided into study group and control group with 106 cases each. The study group was treated with alprostadil adjuvant intervention and the control group was treated with atorvastatin adjuvant therapy. The two groups were treated separately Serum levels of Hcy, SOD and IL-23 were detected before and after treatment. Results The levels of serum Hcy and IL-23 in both groups decreased after treatment. The levels of SOD in the two groups before treatment were higher than those before treatment, and the changes in the study group were greater than those in the control group. The differences were statistically significant (P <0.05). Conclusions Alprostadil is more effective in lowering serum Hcy and IL-23 levels and increasing serum SOD than alprostadil-assisted intervention in the treatment of unstable angina pectoris.