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对以M_1型为优势的耐氯霉素等抗菌药物的伤寒菌株引起的220例伤寒患者进行了药物治疗观察,发现氟哌酸、氟哌酸与甲氧苄氨嘧啶、氟哌酸与庆大霉素联台治疗组的疗效优于氯霉素或含氯霉素的联合治疗组。采用氟哌酸治疗无严重全身毒副反应,未见复燃或复发病例,费用亦经济。一般病例单用氟哌酸即可,重症病例可与其他抗菌药物联合治疗。在广泛存在耐药菌株流行的情况下,应首选氟哌酸治疗伤寒。
220 cases of typhoid fever caused by typhoid strains resistant to chloramphenicol and other antibiotics with M_1 type were observed and found that norfloxacin, norfloxacin and trimethoprim, norfloxacin and Qingda The efficacy of combination therapy with moxifloxacin was better than that with chloramphenicol or chloramphenicol. Norfloxacin treatment without serious systemic side effects, no recurrence or recurrence of cases, the cost is also economical. Norfloxacin can be used alone in normal cases, severe cases can be combined with other antibacterial drugs. In the prevalence of drug-resistant strains of widespread prevalence, norfloxacin should be the preferred treatment of typhoid fever.