目的　研究染料木黄酮胶囊在SD大鼠体内的生物利用度。方法　采用HPLC法以SD大鼠为研究对象 ,测定染料木黄酮注射液和染料木黄酮胶囊单剂量给药后的血药浓度 ,用 3P87计算药动学参数和生物利用度。结果　染料木黄酮胶囊剂的 :AUC =3.318μg·ml-1·h-1,MRT =2 0 .335h ,Cmax　 =0 .2 0 6 7μg·ml-1,tpeak　 =4h ,生物利用度为 5 6 .4 9%。结论　该研究为染料木黄酮胶囊的内在质量评价及方剂组成的改造提供了一定的依据。 Objective To study the bioavailability of genistein capsules in SD rats. Methods SD rats were used as the research object to determine the plasma concentrations of genistein and genistein capsules after single dose administration. The pharmacokinetic parameters and bioavailability were calculated using 3P87. Results Genistein capsules: AUC = 3.318 μg·ml-1·h-1, MRT = 2 0 .335 h, Cmax = 0.27 6 μg·ml-1, tpeak = 4 h, bioavailability was 5 6.4 percent. Conclusion This study provides a basis for the evaluation of the intrinsic quality of genistein capsules and the transformation of prescriptions.