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【摘要】目的：探讨血必净注射液联合注射用亚胺培南西司他丁钠在重症肺炎患者治疗效果及对PCT、CRP、WBC指标水平的影响。方法：选择2017年5月至2020年4月重症肺炎患者68例作为对象，随机分为对照组（n=34例）和观察组（n=34例）。对照组给予注射用亚胺培南西司他丁钠治疗，观察组采用血必净注射液联合注射用亚胺培南西司他丁钠治疗，治疗一个月后对患者效果进行评估，比较两组治疗前后的PCT、CPR、WBC水平的变化情况及预后。结果：观察组用药1个月后PCT、CRP、WBC低于对照组（P<0.05），两组治疗过程中恶心呕吐、腹泻便秘、血压波动、皮疹过敏、肝肾异常发生率无统计学意义（P>0.05）。结论：血必净注射液联合注射用亚胺培南西司他丁钠能降低重症肺炎患者炎性因子水平，提高患者的生活质量，能获得良好的治疗预后，值得推广应用。
【关键词】重症肺炎患者；血必净注射液；注射用亚胺培南西司他丁钠；PCT；CPR；WBC
[中图分类号]R563.1 [文献标识码]A [文章编号]2096-5249（2021）09-0073-02
Effect of Xuebijing injection combined with imipenem cilastatin sodium for injection in the treatment of severe pneumonia and its influence on PCT， CRP and WBC
XU ming-xiong， LIAO Shen-fu， LUO lin-li（Department of critical care medicine， Dongguan Third Bureau hospital， Dongguan Guangdong523710， China）
[Abstract] Objective： To investigate the effect of Xuebijing injection combined with imipenem cilastatin sodium for injection in the treatment of severe pneumonia and its influence on PCT， CRP and WBC. Methods： 68 patients with severe pneumonia from May 2017 to April 2020 were randomly divided into control group （n = 34） and observation group （n = 34）. The control group was treated with imipenem cilastatin sodium for injection， while the observation group was treated with Xuebijing injection combined with imipenem cilastatin sodium for injection. The effect of the patients was evaluated after one month of treatment. The changes of PCT， CPR， WBC levels and the clinical prognosis of the two groups before and after treatment were compared. Results： the levels of PCT， CRP and WBC in the observation group were lower than those in the control group after one month of treatment （P < 0.05）. The incidence of nausea and vomiting， diarrhea and constipation， blood pressure fluctuation， rash allergy， liver and kidney abnormalities in the two groups were not statistically significant （P > 0.05）. Conclusion： the effect of Xuebijing injection combined with imipenem cilastatin sodium for injection in the treatment of severe patients can improve the clinical inflammatory reaction of patients， improve the quality of life of patients， and obtain good treatment prognosis， which is worthy of promotion and application.
[Key words] Severe pneumonia patients； Xuebijing injection； Imipenem cilastatin sodium for injection； PCT； CPR； WBC
肺炎是一種以呼吸困难为主要症状的疾病，该疾病的发生人群广泛，可以发生于婴幼儿高热不退导致的重症肺部炎症，也可以发生在大型手术术后肺部严重感染或者是年老体衰患者的肺部严重感染[1]。临床上肺部感染十分常见，迁延不愈则会进展为重症肺部炎症，现代医学中的治疗多是注射用亚胺培南西司他丁钠治疗，用于改善患者的临床体征，但是实际疗效并不显著。现代药理结果表明：注射用亚胺培南西司他丁钠属于广谱抗生素的一种，对于青霉素、蛋白质具有较高的亲和力，但是我国注射用亚胺培南西司他丁钠耐药性较高，导致患者远期预后较差。血必净注射液属于临床常用的中成药，能发挥活血化瘀、理气功效，可减轻心肌循环的能量供应。临床上的治疗多是亚胺培南西司他丁钠治疗，联合治疗较少[2]，因此，本研究中以重症肺炎患者作为对象，探讨血必净注射液联合注射用亚胺培南西司他丁钠在重症肺炎患者中的治疗效果，报道如下。
【关键词】重症肺炎患者；血必净注射液；注射用亚胺培南西司他丁钠；PCT；CPR；WBC
[中图分类号]R563.1 [文献标识码]A [文章编号]2096-5249（2021）09-0073-02
Effect of Xuebijing injection combined with imipenem cilastatin sodium for injection in the treatment of severe pneumonia and its influence on PCT， CRP and WBC
XU ming-xiong， LIAO Shen-fu， LUO lin-li（Department of critical care medicine， Dongguan Third Bureau hospital， Dongguan Guangdong523710， China）
[Abstract] Objective： To investigate the effect of Xuebijing injection combined with imipenem cilastatin sodium for injection in the treatment of severe pneumonia and its influence on PCT， CRP and WBC. Methods： 68 patients with severe pneumonia from May 2017 to April 2020 were randomly divided into control group （n = 34） and observation group （n = 34）. The control group was treated with imipenem cilastatin sodium for injection， while the observation group was treated with Xuebijing injection combined with imipenem cilastatin sodium for injection. The effect of the patients was evaluated after one month of treatment. The changes of PCT， CPR， WBC levels and the clinical prognosis of the two groups before and after treatment were compared. Results： the levels of PCT， CRP and WBC in the observation group were lower than those in the control group after one month of treatment （P < 0.05）. The incidence of nausea and vomiting， diarrhea and constipation， blood pressure fluctuation， rash allergy， liver and kidney abnormalities in the two groups were not statistically significant （P > 0.05）. Conclusion： the effect of Xuebijing injection combined with imipenem cilastatin sodium for injection in the treatment of severe patients can improve the clinical inflammatory reaction of patients， improve the quality of life of patients， and obtain good treatment prognosis， which is worthy of promotion and application.
[Key words] Severe pneumonia patients； Xuebijing injection； Imipenem cilastatin sodium for injection； PCT； CPR； WBC
肺炎是一種以呼吸困难为主要症状的疾病，该疾病的发生人群广泛，可以发生于婴幼儿高热不退导致的重症肺部炎症，也可以发生在大型手术术后肺部严重感染或者是年老体衰患者的肺部严重感染[1]。临床上肺部感染十分常见，迁延不愈则会进展为重症肺部炎症，现代医学中的治疗多是注射用亚胺培南西司他丁钠治疗，用于改善患者的临床体征，但是实际疗效并不显著。现代药理结果表明：注射用亚胺培南西司他丁钠属于广谱抗生素的一种，对于青霉素、蛋白质具有较高的亲和力，但是我国注射用亚胺培南西司他丁钠耐药性较高，导致患者远期预后较差。血必净注射液属于临床常用的中成药，能发挥活血化瘀、理气功效，可减轻心肌循环的能量供应。临床上的治疗多是亚胺培南西司他丁钠治疗，联合治疗较少[2]，因此，本研究中以重症肺炎患者作为对象，探讨血必净注射液联合注射用亚胺培南西司他丁钠在重症肺炎患者中的治疗效果，报道如下。