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为探讨食用油烟对巨噬细胞膜脂流动性的影响，选用ＳＤ大鼠于染毒柜中自然吸入食用豆油油烟，急性染毒，观察到油烟平均浓度为１．０５ｍｇ／ｍ３时，肺组织发生脂质过氧化，ＭＤＡ开始增加（Ｐ＜０．０５）；平均浓度为９．５８ｍｇ／ｍ３时，肺泡灌洗液（ＢＡＬＦ）中肺巨噬细胞（ＰＡＭ）膜脂流动性（ＬＦＵ）增加（Ｐ＜０．０１），且ＬＤＨ、ＡＣＰ酶的活力升高（Ｐ＜０．０５）。吸入油烟浓度与各指标间有显著的剂量－反应关系。结果提示，食用油烟在本实验条件下可引起ＰＡＭ膜脂流动性的增加。
In order to investigate the effect of edible fume on the membrane fluidity of macrophages, SD rats were naturally inhaled with soybean oil fume in the exposure cabinet and acutely exposed to the virus. When the average concentration of fume was 1.05mg / m3, the lung tissues were observed Lipid peroxidation and MDA began to increase (P <0.05). When the average concentration was 9.58mg / m3, the membrane fluidity of lipids (PAMU) in BALF increased P <0.01), and LDH, ACP enzyme activity increased (P <0.05). There was a significant dose-response relationship between smoke inhalation concentration and each index. The results suggest that edible soot in this experimental conditions can cause increased fluidity of PAM membrane lipids.