为了探讨内皮细胞舒张因子合成抑制产生之心血管病理生理变化及意义.本研究长期给大鼠腹腔注射内皮细胞舒张因子抑制剂—左旋硝基精氨酸,发现大鼠血压明显持续性增高、心率减慢、心功能代偿性增强,主动脉环对去甲肾上腺素和内皮素收缩反应增强,对乙酸胆碱舒张反应减低,血浆和组织内皮素(ET)增高,组织—磷酸乌苷活性减低,血浆血管紧张素Ⅱ和肾素活性减低,血浆丙二醛增高.病理显示肾小球动脉内皮细胞增生,内膜增厚,内膜下玻璃样变性. In order to investigate the cardiovascular pathophysiological changes and the significance of the synthesis inhibition of endothelial cell relaxing factor synthesis.In this study, long-term intraperitoneal injection of endothelial cell relaxation factor inhibitor - L-nitro-arginine, found that blood pressure was significantly increased continuously, heart rate Slowed down, compensatory enhancement of heart function, aortic rings increased norepinephrine and endothelin contractile response, decreased diacetate acetate diastolic response, plasma and tissue endothelin (ET) increased, tissue-phosphoglucoside activity decreased , Plasma angiotensin Ⅱ and renin activity decreased, plasma malondialdehyde increased.The pathological changes of glomerular arterial endothelial cell proliferation, intimal thickening, subintimal vitreous degeneration.