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目的:研究优思明联合二甲双胍对多囊卵巢综合征(PCOS)患者内分泌的影响。方法:选择临床确诊为P-COS患者65例,采用优思明和二甲双胍联合治疗6月,治疗前后分别测定血清黄体生成素(LH)、促卵泡素(FSH)、雌二醇(E2)、睾酮(T)、空腹胰岛素(FIN)、空腹血糖(FBS)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)水平。结果:经治疗6个月后,LH、LH/FSH、T的水平均较治疗前明显降低(P<0.05),但FSH、E2下降不明显(P>0.05);治疗后FIN和胰岛素抵抗指数明显改善(P<0.01);TC、TG下降明显(P<0.05),HDL-C升高明显(P<0.05);治疗期间均未出现严重不良反应。结论:优思明联合二甲双胍应用能明显改善PCOS患者性激素水平,降低体内雄激素水平,改善胰岛素抵抗指数,纠正体内异常脂质代谢,降低患者心血管并发症的风险,值得临床推广。
Objective: To study the effects of combination of metformin and metformin on endocrine in patients with polycystic ovary syndrome (PCOS). Methods: Sixty-five patients were diagnosed as P-COS. The patients were treated with Yasmin and metformin for 6 months. Serum levels of LH, FSH, T and T were measured before and after treatment. Fasting insulin (FIN), fasting blood glucose (FBS), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and total cholesterol (TC) Results: The levels of LH, LH / FSH and T were significantly lower than those before treatment (P <0.05), but the levels of FSH and E2 were not significantly decreased (P> 0.05) after 6 months of treatment. FIN and insulin resistance index (P <0.01); TC, TG decreased significantly (P <0.05), HDL-C increased significantly (P <0.05); No serious adverse reactions occurred during the treatment. Conclusion: The combination of YSM in combination with metformin can significantly improve the level of sex hormone in PCOS patients, reduce the level of androgen in the body, improve the index of insulin resistance, correct abnormal lipid metabolism in vivo and reduce the risk of cardiovascular complications in patients with PCOS, worthy of clinical promotion.