全胃切除术对儿童卓艾综合征(简称 ZES)的影响一直存在着争论。自1977年组胺 H_2受体拮抗剂在美国问世以来,胃酸分泌有效抑制剂在药物治疗 ZES 中具有重要意义。有些患 ZES 伴转移的年轻病人有可能在短期内死于胃泌素肿瘤的生长,那么应用新型更可靠的胃酸分泌抑制剂治疗或许比全胃切除术更合适?同时,许多外科医 There has been controversy over the effect of total gastrectomy on Zhuo’ai syndrome (ZES) in children. Since histamine H_2 receptor antagonists were introduced in the United States in 1977, effective inhibitors of gastric acid secretion have been of great significance in drug therapy ZES. Some young patients with ZES with metastases may die of gastrin tumors in the short term. Therefore, the application of new and more reliable gastric acid secretion inhibitors may be more appropriate than total gastrectomy. Meanwhile, many surgeons