论文部分内容阅读
环氧化酶(COX)是花生四烯酸合成前列腺素(PGs)的限速酶,有两种亚型,即COX-1和COX-2,近来研究表明COX-2在消化系统肿瘤尤其是胃癌的发生发展、分化、转移等方面有重要作用。胃黏膜COX-2表达与幽门螺旋杆菌(Hp)感染有一定关系,COX-2特异性抑制剂有望成为肿瘤防治的一类新药。
Cyclooxygenase (COX) is a rate-limiting enzyme for the synthesis of prostaglandins (PGs) from arachidonic acid. There are two subtypes, COX-1 and COX-2. Recent studies have shown that COX- The occurrence and development of gastric cancer, differentiation, metastasis and other aspects have an important role. Gastric mucosa COX-2 expression and Helicobacter pylori (Hp) infection have a certain relationship, COX-2-specific inhibitor is expected to become a class of new drugs for the prevention and treatment of cancer.