论文部分内容阅读
目的评价丙泊酚和异氟醚对老年脑膜瘤患者的炎性作用,分析细胞黏附分子1(ICAM-1)、白细胞介素1(IL-1)和肿瘤坏死因子α(TNF-α)的变化。方法老年脑膜瘤手术患者65例,随机分为丙泊酚组和异氟醚组,丙泊酚组患者血浆靶控输注丙泊酚3~6μg/m L,异氟醚组患者1%~2%异氟醚持续吸入;2组患者分别于麻醉诱导前、术后0、24、48 h各抽取静脉血5 m L,测定血清ICAM-1、IL-1、TNF-α含量。结果丙泊酚组老年脑膜瘤患者与异氟醚组比较,术后24和48 h丙泊酚组ICAM-1、IL-1、TNF-α含量均较异氟醚组降低(均P<0.05);2组患者血清ICAM-1、IL-1、TNF-α含量术后均呈上升趋势,各指标各检测点间差异均有统计学意义(均P<0.001)。结论丙泊酚靶控输注比异氟醚吸入可更好地降低老年脑膜瘤患者术后炎性作用。
Objective To evaluate the inflammatory effects of propofol and isoflurane on elderly patients with meningioma and to analyze the correlation between the expression of ICAM-1, IL-1 and TNF-α Variety. Methods Sixty-five elderly patients with meningioma were randomly divided into two groups: propofol group and isoflurane group, propofol 3 ~ 6μg / m L target group, and propofol group 1% 2% isoflurane inhalation. The venous blood samples were taken from the two groups before anesthesia induction, 0,24 and 48 h after operation respectively. The levels of serum ICAM-1, IL-1 and TNF-α were measured. Results Compared with isoflurane group, the levels of ICAM-1, IL-1 and TNF-α in propofol group were lower than those in isoflurane group at 24 and 48 h postoperatively (all P <0.05 ). Serum levels of ICAM-1, IL-1 and TNF-α in the two groups all showed an upward trend after operation, with significant differences between the various test points (all P <0.001). Conclusion Propofol target-controlled infusion of isoflurane inhalation can better reduce postoperative inflammatory effects in elderly patients with meningioma.