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维生素D为抗佝偻病因子,是古老的脂溶性维生素之一。近15年来D的研究迅猛发展,70年代初期美国威斯康星大学De Luca,加利福尼亚大学诺曼和英国剑桥大学Kodicek三个组从分子水平研究D的作用机制,同时发现在机体内D经肝和肾两步代谢成活性维生素D,即1α,25-二羟基胆钙化醇(1α,25-(OH)_2-D_3)才发挥其生理功能。它促进肠吸收钙和骨动员钙,与甲状旁腺激素(pTH)和降钙素一起维持钙和磷的内环境恒定。它在血循环中及细胞内
Vitamin D is anti-rickets disease factor, is one of the oldest fat-soluble vitamins. During the past 15 years, the research of D has been developing rapidly. In the early 1970s, De Luca of the University of Wisconsin, Norman of the University of California, and Kodicek of the University of Cambridge in the United Kingdom studied the mechanism of D at the molecular level. In the meantime, Metabolic into active vitamin D, 1α, 25-dihydroxycholecalciferol (1α, 25- (OH) _2-D_3) to play its physiological function. It promotes intestinal absorption of calcium and mobilizing calcium, together with parathyroid hormone (pTH) and calcitonin to maintain a constant calcium and phosphorus homeostasis. It is in the blood circulation and intracellular