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目的研究口服丙硫氧嘧啶对妊娠合并甲状腺功能亢进患者甲状腺激素水平及妊娠结局的影响。方法选取贵港市中医医院内二科2012年2月—2015年2月收治的36例妊娠合并甲状腺功能亢进患者为试验组,在常规用药基础上口服丙硫氧嘧啶治疗。另取40例仅常规用药的妊娠合并甲状腺功能亢进患者为对照组。检测两组促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)水平、游离三碘甲状腺原氨酸指数(FT3I)及游离甲状腺素指数(FT4I),并对比两组患者的妊娠结局。结果试验组患者TSH水平高于对照组,FT3、FT4水平、FT3I及FT4I均低于对照组,差异有统计学意义(P<0.05);试验组不良结局发生率为5.6%(2/36),对照组为37.5%(15/40),试验组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05)。结论治疗妊娠合并甲状腺功能亢进疾病时可在常规用药基础上口服丙硫氧嘧啶治疗,有效改善甲状腺激素水平,有助于患者顺利产下新生儿,具有较好的临床效果。
Objective To investigate the effect of oral propylthiouracil on thyroid hormone levels and pregnancy outcomes in patients with hyperthyroidism during pregnancy. Methods Thirty-six patients with pregnancy complicated with hyperthyroidism admitted from February 2012 to February 2015 in Guigang Hospital of Traditional Chinese Medicine were selected as the experimental group and treated with propylthiouracil on the basis of routine medication. Another 40 cases of conventional medication for pregnant women with hyperthyroidism as the control group. (TSH), free triiodothyronine (FT3), free thyroxine (FT4), free triiodothyronine (FT3I) and free thyroxine index (FT4I) Pregnancy outcomes were compared between the two groups. Results The level of TSH in the experimental group was higher than that in the control group. The levels of FT3 and FT4, FT3I and FT4I in the experimental group were significantly lower than those in the control group (P <0.05). The incidence of adverse outcomes in the experimental group was 5.6% (2/36) , While the control group was 37.5% (15/40). The incidence of adverse pregnancy outcomes in the experimental group was lower than that in the control group (P <0.05). Conclusion The treatment of hyperthyroidism during pregnancy can be oral administration of propylthiouracil on the basis of conventional medication, which can effectively improve the level of thyroid hormone and help patients to successfully deliver newborns with good clinical results.