生促红素人肝细胞(erythropoietin-producing human hepatocelluar,Eph)属于受体酪氨酸激酶(receptor tyrosine kinases,RTKs)超家族中最大的一个亚族,EphA2是Eph受体之一,广泛表达在人类上皮来源的多种组织或细胞系中,对调节细胞生长、迁移及血管形成有潜在的作用。EphA2过表达可导致细胞的恶性转化,促进肿瘤的侵袭和转移。EphA2的过表达可以作为评估肿瘤的恶性程度及预测患者预后的指标,并有望成为肿瘤治疗的新靶点。 Eph belongs to the largest subfamily of receptor tyrosine kinases (RTKs), and EphA2 is one of the Eph receptors. It is widely expressed in human Many tissues or cell lines of epithelial origin have a potential role in the regulation of cell growth, migration and angiogenesis. Overexpression of EphA2 leads to malignant transformation of cells and promotes tumor invasion and metastasis. Overexpression of EphA2 can be used as an indicator to assess the malignancy of the tumor and predict the prognosis of patients, and is expected to become a new target of tumor therapy.