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目的:研究肺癌患者体液免疫指标血清球蛋白IgG、IgA、lgM及补体3(C3)、补体4(C4)在化疗前后的变化。方法:测定100例肺癌患者的血清免疫球蛋白IgG、IgM、IgA及C3、C4的含量,并和肺炎和健康对照相比较。结果:肺癌组的IgG、IgA、IgM及C3、C4比肺炎组和正常人显著升高(P<0.01和P<0.05),肺癌患者化疗后有效组C3、C4明显低于化疗前患者的。结论:对肺癌患者体液免疫指标的观察可作为疗效观查的指标。
OBJECTIVE: To study the changes of serum immunoglobulin IgG, IgA, IgM, complement 3 (C3) and complement 4 (C4) in patients with lung cancer before and after chemotherapy. Methods: Serum immunoglobulin IgG, IgM, IgA and C3, C4 were measured in 100 cases of lung cancer patients and compared with pneumonia and healthy controls. Results: The levels of IgG, IgA, IgM and C3, C4 in lung cancer group were significantly higher than those in pneumonia group and normal group (P <0.01 and P <0.05). The levels of C3 and C4 in effective group were significantly lower than those before chemotherapy in lung cancer group. Conclusion: The observation of humoral immunity in lung cancer patients can be used as an indicator of efficacy.