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儿童未成熟畸胎瘤成分复杂,具有潜在恶性。特异性肿瘤标志物、肿瘤生物学行为的进一步研究将为临床诊疗、随访、预后评估提供更多的客观指标。文章就目前国内外比较有争议的肿瘤标志物包括AFP异质体L3、神经元特异性烯醇化酶、波形蛋白、神经细胞特异抗原等,并结合癌基因和抑癌基因、细胞周期相关抗原和端粒酶、染色体核型分析等进行归纳总结,为临床治疗和随访提供病理和生物学上的资料,为临床治疗和预后评估提供参考。
Children immature teratoma complex composition, with potential malignancy. Specific tumor markers, tumor biological behavior of further research for clinical diagnosis and treatment, follow-up, prognosis assessment to provide more objective indicators. At present, more controversial tumor markers at home and abroad include AFP heterogeneity L3, neuron-specific enolase, vimentin, nerve cell-specific antigens, combined with oncogenes and tumor suppressor genes, cell cycle associated antigen and Telomerase, chromosome karyotype analysis and so on to summarize, for clinical treatment and follow-up to provide pathological and biological information for clinical treatment and prognosis assessment provide a reference.