目的了解南京地区重症手足口病(HFMD)的流行病学规律,探索正确的应对措施。方法利用国家疾病监测网络直报信息系统,对本地区194例重症HFMD资料进行临床流行病学分析。结果 2009年南京地区重症HFMD的发病率为2.55/10万。其中,外来人口HFMD的发病率为3.13/10万,南京本地为2.20/10万。194例重症HFMD患儿中,3岁以下148例,占76.28%,男女比例为1.85∶1;通过对194例的病原学分析表明,肠道病毒71阳性63例(32.47%),COX A16阳性16例(8.25%)。结论 HFMD患儿,尤其是3岁以下的患儿高发,病程在5d以内发生。应控制感染源,加强HFMD监测,降低重症HFMD病死率。 Objective To understand the epidemiology of severe hand-foot-mouth disease (HFMD) in Nanjing and to explore the correct countermeasures. Methods The National Epidemiology Report of Disease Surveillance Network was used to analyze 194 cases of severe HFMD in this area. Results The incidence of severe HFMD in Nanjing was 2.55 / 100,000 in 2009. Among them, the incidence of foreign population HFMD was 3.13 / 100,000, Nanjing local 2.20 / 100,000. Among 194 cases of severe HFMD, 148 cases were below 3 years old, accounting for 76.28%. The ratio of male to female was 1.85:1. The etiological analysis of 194 cases showed that 71 cases of enterovirus 71 were positive (32.47%), positive for COX A16 16 cases (8.25%). Conclusion HFMD in children, especially in children under 3 years of age high incidence of disease within 5d occurred. Should control the source of infection, strengthen HFMD monitoring, reduce the mortality of severe HFMD.