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Hirsch等在鼠甲状腺中首次发现,可降低血浆钙和磷酸盐的激素——降钙素(CT)是由32个氨基酸残基所组成。血浆CT主要来源于甲状腺中的C-细胞。然而近年来,在甲状腺外的多处部位,如胸腺、垂体、肺、肠和其他一些组织也发现有CT免疫反应(IR-CT)。某些研究表明,甲状腺缺如时,血浆和尿中仍可检出IR-CT,另一方面,异位产生IR-CT常与小细胞肺癌、乳腺癌和其他各种肿瘤(包括胃癌)有关。Schwartz等观察在10例胃癌病人中,3例血浆IR-CT水平开高。目前尚未见有关人胃粘膜和肿瘤中采用免疫组织化学检测CT的报道。本文采用免疫组织化学过氧化酶-抗过氧化酶方法,以研究IR-CT在正常或胃炎时胃粘膜和胃腺瘤及胃癌肿瘤细胞中的定位。在婴儿和成人胃窦粘膜中观察到含IR-CT的少量细胞,含IR-CT与G-细胞的比例约为1:50～
Hirsch et al. discovered for the first time in the rat thyroid gland that the hormone that reduces plasma calcium and phosphate—calcitonin (CT) consists of 32 amino acid residues. Plasma CT is mainly derived from C-cells in the thyroid gland. However, in recent years, CT immunoreactivity (IR-CT) has also been found in multiple sites outside the thyroid, such as thymus, pituitary, lung, intestine, and other tissues. Some studies have shown that IR-CT can still be detected in plasma and urine when thyroid is absent. On the other hand, ectopically generated IR-CT is often associated with small cell lung cancer, breast cancer and other various tumors (including gastric cancer). . Schwartz et al. observed that plasma IR-CT levels were high in 3 of 10 patients with gastric cancer. At present, there have been no reports on the use of immunohistochemical detection of CT in human gastric mucosa and tumors. This article uses immunohistochemical peroxidase-anti-peroxidase method to study the localization of IR-CT in normal or gastritis gastric mucosa, gastric adenoma and gastric cancer tumor cells. A small number of cells containing IR-CT were observed in the antral mucosa of infants and adults. The ratio of IR-CT to G-cells was approximately 1:50-