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甾类激素避孕药(包括复方口服避孕药、长效醋酸甲孕酮注射剂)因使用简便、高效在欧、美等国家广泛应用。其作用于下丘脑-垂体轴导致卵巢激素分泌降低,但对骨代谢和骨矿物质密度的影响报道不一。可能与服药时间、随访时间、参与研究人群的年龄等因素有关。回顾近年有关复方口服避孕药、长效醋酸甲孕酮注射剂对骨矿物质影响的研究,阐述青春期、性成熟期和绝经期女性应用甾类避孕药与骨矿物质密度的关系,同时讨论对骨折的影响。
Steroid hormonal contraceptives (including oral contraceptives, long-acting medroxyprogesterone acetate injection) due to ease of use, high efficiency in Europe, the United States and other countries widely used. Its role in the hypothalamus - pituitary axis leads to reduced ovarian hormone secretion, but the impact of bone metabolism and bone mineral density reported differently. May be related to medication time, follow-up time, age of participation in the study and other factors. Review of recent years on the compound oral contraceptives, long-term effects of medroxyprogesterone acetate injection on bone mineral content, described adolescent, sexual maturity and menopausal women steroid contraceptives and bone mineral density, while discussing the fracture Impact.