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[目的]观察通过自体骨髓间充质干细胞移植治疗脑出血的近期临床疗效。[方法]选取神经内科收治住院治疗的280例脑出血患者作为治疗组,行手术血肿清除术后,通过腰椎穿刺蛛网膜下腔注射自体骨髓间充质干细胞悬液3.5ml。选择同期入院300例患者作为对照组。分别于移植前后6个月进行神经功能缺损程度评定(NIHSS评分)和日常生活活动能力评定(Barthel指数),行颅脑MRI、血生化指标,监测干细胞移植的安全性。[结果]治疗组移植6个月后与对照组及移植前比较,NIHSS评分均有显著降低(P﹤0.01),Barthel指数均有显著升高(P﹤0.01)。移植后6个月随访,颅脑MRI及血生化指标均未出现明显异常。[结论]自体骨髓间充质干细胞移植治疗脑出血是安全可行的,且在近期内疗效确定,远期疗效尚待进一步观察。
[Objective] To observe the short-term clinical efficacy of autologous bone marrow mesenchymal stem cell transplantation in the treatment of cerebral hemorrhage. [Methods] A total of 280 patients with intracerebral hemorrhage admitted to hospital for neurology were selected as the treatment group. After surgical hematoma removal, 3.5 ml of autologous bone marrow mesenchymal stem cell suspension was injected through the subarachnoid space of the lumbar puncture. Select the same period of admission of 300 patients as a control group. The degree of neurological deficit (NIHSS score) and activity of daily living (Barthel index) were evaluated 6 months before and after transplantation. The brain MRI and blood biochemical indexes were used to monitor the safety of stem cell transplantation. [Results] The NIHSS scores of the treatment group were significantly decreased (P <0.01) and Barthel index (P <0.01) 6 months after transplantation compared with the control group and before transplantation. Six months after transplantation, follow-up of brain MRI and blood biochemical indicators showed no significant abnormalities. [Conclusion] Autologous bone marrow mesenchymal stem cell transplantation is safe and feasible for the treatment of intracerebral hemorrhage. The curative effect in the near future is confirmed. The long-term curative effect needs further observation.