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目的：科学地衡量抗凝血剂对凝血酶原的破坏程度，比较第一代与第二代抗凝血剂对褐家鼠和小白鼠的毒杀能力。方法：以急性口服ＬＤ５０和半ＬＤ５０剂量对褐家鼠和小白鼠各灌胃１０只，每２４小时取尾部静脉血，用改良奎克氏全血法测定凝血酶原时间。结果：褐家鼠２４小时左右凝血酶原时间明显延长，４８小时大部分试鼠凝血酶原时间超过２００秒并出现死亡，１２０小时内绝大部分试鼠死亡。小白鼠在２４小时左右凝血酶原时间稍有延长，４８小时基本恢复正常，７２小时急速延长到２００秒以上，大部分试鼠在１６８小时内死亡。凝血酶原时间呈双峰型。结论：褐家鼠对３种抗凝血剂都敏感，小白鼠敏感性略低，尤其褐家鼠对敌鼠钠盐敏感性甚强，在以褐家鼠为优势种的地区，敌鼠钠盐不失为一种上佳灭鼠剂
OBJECTIVE: To scientifically measure the degree of prothrombin destruction by anticoagulants and to compare the virulence of the first and second generation anticoagulants to Rattus norvegicus and mice. Methods: Acute oral LD50 and LD50 doses of Rattus norvegicus and mice were intragastric administration of 10, every 24 hours to take the tail venous blood, using modified Quaker’s whole blood method for the determination of prothrombin time. Results: Rattus norvegicus for 24 hours significantly prolonged prothrombin time, 48 hours most of the test rats prothrombin time more than 200 seconds and died, the vast majority of rats died within 120 hours. Prolonged prothrombin time of mice in the 24 hours slightly extended, 48 hours basically returned to normal, 72 hours rapidly extended to more than 200 seconds, most of the rats died within 168 hours. Prothrombin time was bimodal. CONCLUSION: Rattus norvegicus is sensitive to all the three anticoagulants and its sensitivity is slightly low. In particular, Rattus norvegicus is very sensitive to the sodium salt of the antagonist. In areas where Rattus norvegicus is the dominant species, it is a good choice Rodenticide