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目的探讨中西医结合治疗高血压合并糖尿病的临床疗效。方法选取2013年3月—2014年3月扶沟县中医院收治的高血压合并糖尿病患者90例,随机分为对照组与研究组,各45例。对照组患者予以西医治疗,研究组患者在对照组基础上予以中医治疗。观察两组患者治疗前后血压(舒张压、收缩压)变化情况、肾功能指标(血肌酐、血尿素氮、24h尿清蛋白)、临床疗效及不良反应发生情况。结果治疗前两组患者舒张压、收缩压比较,差异无统计学意义(P>0.05),治疗后研究组患者舒张压、收缩压低于对照组,差异有统计学意义(P<0.05);治疗前两组患者血肌酐、血尿素氮和24h尿清蛋白水平比较,差异无统计学意义(P>0.05),治疗后研究组患者血肌酐、血尿素氮和24h尿清蛋白水平低于对照组,差异有统计学意义(P<0.05);研究组患者总有效率高于对照组,差异有统计学意义(P<0.05);两组患者均未发生严重不良反应。结论中西医结合治疗高血压合并糖尿病的临床疗效显著,可降低患者血压,改善患者肾功能,且不良反应少。
Objective To explore the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of hypertension complicated with diabetes mellitus. Methods Totally 90 hypertensive patients with diabetes admitted to Fugou Chinese Medicine Hospital from March 2013 to March 2014 were randomly divided into control group and study group, with 45 cases in each group. The patients in the control group were treated with western medicine. The patients in the study group were treated with Chinese medicine on the basis of the control group. The changes of blood pressure (diastolic blood pressure and systolic blood pressure) and the indexes of renal function (serum creatinine, blood urea nitrogen and 24h urinary albumin) before and after treatment were observed before and after treatment. The clinical efficacy and adverse reactions were observed. Results There was no significant difference in diastolic blood pressure and systolic blood pressure between the two groups before treatment (P> 0.05). After treatment, the diastolic blood pressure and systolic blood pressure were lower in the study group than in the control group (P <0.05) The serum creatinine, blood urea nitrogen and 24h urinary albumin levels of the first two groups had no significant difference (P> 0.05). The serum creatinine, blood urea nitrogen and 24h urinary albumin level in the study group were lower than those in the control group , The difference was statistically significant (P <0.05). The total effective rate of study group was higher than that of control group, the difference was statistically significant (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Integrative treatment of hypertension with diabetes clinical significant effect, can reduce blood pressure, improve renal function, and less adverse reactions.