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目的:研究活血通络膏对大鼠神经根性疼痛的影响。方法:采用大鼠神经根型颈椎病动物模型,术后外用贴敷活血通络膏0.4,0.2,0.1g·kg-1,以强生关节止痛膏为阳性对照,1次/d,连续用药15 d,观察大鼠手术后每日自主行为及对神经根炎症的反应程度,测定大鼠压足痛阈值,作颈神经根病理组织学观察。结果:活血通络膏高、中剂量可明显提高神经根炎大鼠压足痛阈值,改善神经根病变程度,促进模型动物行为学改变的恢复。结论:活血通络膏对大鼠神经根炎疼痛有明显的防治作用。
Objective: To study the effect of Huoxuetongluo on nerve root pain in rats. Methods: The rat model of cervical spondylotic radiculopathy was used. The external application of Huoxuetongluo cream 0.4, 0.2, 0.1g · kg-1 postoperatively, with Johnson & Johnson joint pain relief paste as positive control, once / d, continuous administration 15 d. Observe the daily autonomic behavior and the degree of response to nerve root inflammation after the operation in rats. Threshold of pressure foot pain in rats was measured to observe the pathology of cervical nerve root. Results: High and medium doses of Huoxuetongluo can significantly increase the pressure foot pain threshold of nerve root inflammation rats, improve the degree of nerve root lesions and promote the recovery of behavioral changes in model animals. Conclusion: Huoxuetongluo cream has obvious preventive and therapeutic effects on nerve root inflammation in rats.