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Objective: Early ovarian cancer detection is still very difficult and patients are mostly in advanced stages, with obvious influence on poor prognosis. Method: Fifty- one ovarian cancer patients and 16 healthy controls had the serum concentrations of TNF α receptor p55, p75 and CA- 125 measured prospectively and preoperatively. Result: Mean concentrations of TNFα receptor p55, p75 and CA- 125 in patients with ovarian cancer were higher than in controls. The ratios of p55 and p75 receptor in ovarian cancer and controls were 0.73± 0.38 and 0.55± 0.06 respectively. The areas under ROC curve in detecting malignancy (all FIGO stages) were 0.73, 0.65, 0.88 and 0.85 for p55, p75, p55/p75 ratio and CA- 125 respectively. The areas under ROC curve in detecting stage I of ovarian cancer were 0.52, 0.60, 0.84 and 0.66 for p55, p75, p55/p75 ratio and CA- 125 respectively. Conclusion:Serum TNFα p55/p75 ratio showed promising value in ovarian cancer detection.
Objective: Early ovarian cancer detection is still very difficult and patients are mostly in advanced stages, with obvious influence on poor prognosis. Method: Fifty-one ovarian cancer patients and 16 healthy controls had the serum concentrations of TNFα receptor p55, p75 and CA - 125 measured prospectively and preoperatively. Result: Mean concentrations of TNFα receptor p55, p75 and CA-125 in patients with ovarian cancer were higher than in controls. The ratios of p55 and p75 receptor in ovarian cancer and controls were 0.73 ± 0.38 and 0.55 The areas under ROC curve in detecting malignancy (all FIGO stages) were 0.73, 0.65, 0.88 and 0.85 for p55, p75, p55 / p75 ratio and CA-125 respectively. The areas under ROC curve in detecting stage I of ovarian cancer were 0.52, 0.60, 0.84 and 0.66 for p55, p75, p55 / p75 ratio and CA-125 respectively. Conclusion: Serum TNFα p55 / p75 ratio showed promising value in ovarian cancer detection.