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采用单克隆抗体ＤＯ－１和免疫组化Ｓ－Ｐ法检测了口腔鳞癌和癌前病变组织中Ｐ５３蛋白表达。结果显示，正常口腔粘膜和轻、中度上皮异常增生中Ｐ５３蛋白阴性；３３．３％的上皮重度异常增生和５６．８％的鳞癌Ｐ５３表达阳性，癌组织中Ｐ５３表达与其分化程度、淋巴结转移和临床分期有关。由此作者认为，ｐ５３基因突变是口腔粘膜癌变过程中的早期事件并与口腔癌的进展有关，检测Ｐ５３蛋白有助估计口腔粘膜癌变可能性及口腔癌预后的潜在价值。
The expression of P53 protein in oral squamous cell carcinoma and precancerous lesions was detected by monoclonal antibody DO-1 and immunohistochemistry S-P method. The results showed that normal oral mucosa and mild and moderate epithelial dysplasia P53 protein negative; 33.3% of epithelial dysplasia and 56.8% of squamous cell carcinoma P53 positive expression in cancer tissue P53 expression and differentiation, lymph node Metastasis and clinical stage related. Therefore, the author believes that p53 gene mutation is an early event in the process of oral mucosa carcinogenesis and is related to the progress of oral cancer. Detection of P53 protein may be helpful to evaluate the possibility of oral mucosal carcinogenesis and the potential value of oral cancer prognosis.