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[目的]研究某污灌区农产品中有机污染物对小鼠肝肾组织的氧化损伤。[方法]选取某污灌农田出产的大白菜为研究对象(下称“污灌区”),地下水灌溉农田出产的大白菜为对照(下称“对照区”),采用超声振荡法提取大白菜中的有机污染物,对小鼠灌胃法染毒,共分为5组:对照组(用二甲亚砜染毒),对照区低剂量组、对照区高剂量组、污灌区低剂量组、污灌区高剂量组,每日染毒1次,连续染毒2周。测定肝肾功能指标:草转转氨酶(AST)、谷丙转氨酶(ALT)、γ谷氨酰转肽酶(GGT)、尿酸(UA)、肌肝(Cr)、尿素氮(UN)。[结果]与对照组比较,污灌区高剂量组GGT活性增高(P﹤0.05);污灌区高剂量组的UA含量高于对照区相同染毒剂量组(P﹤0.01)。[结论]该污灌区大白菜中有机提取物中含有致小鼠肝肾功能损伤的有机污染物。
[Objective] The study aimed to study the oxidative damage of liver and kidney in mice by organic pollutants from agricultural products in a sewage irrigation area. [Method] The Chinese cabbage produced from a sewage irrigation farmland was selected as the research object (hereinafter referred to as “sewage irrigation area”) and the Chinese cabbage produced by groundwater irrigation farmland was used as a control (hereinafter referred to as “control area”). The organic pollutants in Chinese cabbage were extracted and the mice were gavaged with gastric cancer. The mice were divided into five groups: the control group (treated with dimethyl sulfoxide), the low-dose control group, the high-dose control group, Low-dose group, high-dose sewage treatment group, once a day exposure, continuous exposure to two weeks. The indicators of liver and kidney function were determined: AST, ALT, GGT, UA, muscle and urea. [Result] Compared with the control group, the GGT activity in the high dose irrigation group was higher (P <0.05). The UA content in the high dose irrigation group was higher than that in the control group (P <0.01). [Conclusion] The organic extracts of Chinese cabbage in the sewage irrigation area contained organic pollutants that caused liver and kidney dysfunction in mice.