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目的 分析围产期各种危险因素对新生儿缺氧缺血性脑病(HIE)发病的影响,寻求预防HIE发生及改善预后的方法。方法对179例HIE患儿性别、出生体重、临床表现、母亲孕期病史及分娩情况进行回顾性分析。同时随机抽取102例同期住院的新生儿肺炎、新生儿黄疸患儿作对照,应用Logistic回归分析的方法筛选HIE发病的危险因素。结果 两组患儿中9个围产因素存在统计学差异。应用Logistic回归分析结果显示:分娩方式、羊水污染、胎膜早破、脐带异常、Apgar评分异常等为主要危险因素。结论 增强孕妇自我保健意识,加强围产期保健,提高基层医疗机构产科质量,根据不同产妇和胎儿的具体情况,采取适当的个体化干预措施,对预防和减少新生儿HIE的发生,降低围产儿死亡率和致残率具有重要意义。
Objective To analyze the influence of various perinatal risk factors on the incidence of neonatal hypoxic-ischemic encephalopathy (HIE) and to find ways to prevent the occurrence of HIE and improve prognosis. Methods A retrospective analysis of 179 HIE children with gender, birth weight, clinical manifestations, mother’s pregnancy history and childbirth were retrospectively analyzed. At the same time, 102 neonates with neonatal pneumonia and neonatal jaundice were randomly selected as controls. Logistic regression analysis was used to screen the risk factors of HIE. Results There were significant differences in the 9 perinatal factors between the two groups. Logistic regression analysis showed that mode of delivery, amniotic fluid contamination, premature rupture of membranes, umbilical cord abnormality and Apgar score were the main risk factors. CONCLUSIONS: To enhance pregnant women’s awareness of self-care, strengthen perinatal care and improve the quality of obstetrics in primary medical institutions. Take appropriate individualized interventions according to the specific conditions of different maternal and fetuses, to prevent and reduce neonatal HIE and reduce perinatal Mortality and morbidity rates are important.