Gag蛋白是 HIV的重要结构蛋白 ,并与病毒出芽密切相关。病毒出芽时 ,Gag蛋白呈空心球体 ,是为Gag前体 ,而后在病毒编码的蛋白酶 (PR)作用下 ,裂解为基质蛋白 MA、衣壳蛋白 CA、核壳蛋白 NC及 P6蛋白 ,而成为成熟毒粒。已有研究表明 PR对 Gag前体的裂解是依序进行的 ,而且正确的 Gag protein is an important structural protein of HIV, and is closely related to the virus budding. When the virus is sprouting, the Gag protein takes the form of a hollow sphere that is a Gag precursor and then cleaves into the matrix protein MA, the capsid protein CA, the nucleocapsid protein NC and the P6 protein under the action of the virus-encoded protease (PR), and becomes mature Poisons. It has been shown that the cleavage of Gag precursors by PR is done in sequence and is correct