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所谓药物性结肠炎一般是指使用抗菌素后发生的结肠炎,又称抗菌素诱发的结肠炎或抗菌系相关的结肠炎。随着化疗的进展,特别是抗菌素的广泛应用,药物性结肠炎的发病近年有上升的趋势,成为一种新的医源性疾病,日益受到临床的普遍关注。据文献报告,引起药物性结肠炎最常见的抗菌素是林可霉素(洁霉素)、氯林可霉素(氯洁霉素)、氨苄青霉素、青霉素及其衍化物;还包括庆大霉素、先锋霉素、新霉素、四环素等。有作者指出,几乎所有抗菌素均可引起药物性结肠炎。本文复习有关药物性结肠炎的近期文献综述如下。
The so-called drug-induced colitis generally refers to the occurrence of colitis after the use of antibiotics, also known as antibiotic-induced colitis or antibiotic-associated colitis. With the progress of chemotherapy, especially the widespread use of antibiotics, the incidence of drug-induced colitis has risen in recent years, becoming a new iatrogenic disease, and has increasingly attracted widespread clinical attention. According to reports in the literature, the most common antibiotics causing drug-induced colitis are lincomycin (clindamycin), clindamycin (clindamycin), ampicillin, penicillin and its derivatives; Prime, cephalosporin, neomycin, tetracycline, etc. Some authors pointed out that almost all antibiotics can cause drug-induced colitis. This article reviews recent literature on drug-induced colitis as follows.