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目的：探讨了慢性丙型肝炎患者血清LDH、TGF-β1和VEGF水平的变化及临床意义。方法应用生化法和酶联免疫法对36例丙型肝炎患者进行了血清LDH、TGF-β1和VEGF水平检测，并与35名正常健康人作比较。结果慢性丙型肝炎患者血清LDH、TGF-β1和VEGF水平均显著地高于正常人组（P<0.01），且血清LDH水平和TGF-β1、VEGF水平呈正相关（r=0.5811，0.6014，P<0.01）。结论检测慢性丙型肝炎患者血清LDH、TGF-β1和VEGF水平的变化对于了解和认识其发病机理及病情预后有一定的帮助。“,”Objective TO explore the clinical Significance of changes of serum LDH、TGF-β1 and VEGF levels in patients with chronic hepatitis C. Methods:serum LDH (with biochemistry) serumTGF-β1.VEGF (with ELISA). Levels were determined in 36 patients with chronic hepatitis C and 35 contrals. Results: serum LDH、TGF-β1 and VEGF levels were significance higher than those in controls . serum LDH levels were positively correlated with serum TGF-β1 , VEGF levels (r=0.5811,0.6014,P<0.01). Conclusion: Determination of changes of serum LDH、TGF-β1 and VEGF levels in patients with chronic hepatitis C might be helpful for outcome prediction.