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目的本研究将通过分析hs-CRP与年龄、血脂、BMI在不稳定心绞痛发生中的相关性及与不稳定心绞痛预后的关系,为选择高危患者及干预治疗提供更多的理论依据。方法对入选的UA患者及接受健康体检的医务人员(对照组)测定高敏C-反应蛋白(hs-CRP),TG、TC、HDL-C、LDL-C,并计算BMI=体质量/身高2。UA患者出院后随访3个月,观察发生顽固心绞痛、急性心梗、心脏猝死情况。结果①不稳定心绞痛组的hs-CRP水平显著高于对照组,差异有显著性意义P<0.05;②BMI、TC与hs-CRP呈显著正相关;HDL-C与hs-CRP呈显著负相关;③发生心脏终点事件hs-CRP水平高于未发生心脏终点事件组P<0.05。结论在不稳定心绞痛患者中进行hs-CRP检测,为高危患者的筛查提供简单、经济、有效的预测,早期干预治疗,降低心血管事件的发生率及死亡率。
Objective This study will provide more theoretical basis for the selection of high-risk patients and intervention treatment by analyzing the correlation between hs-CRP and age, blood lipid, BMI in the occurrence of unstable angina pectoris and prognosis of unstable angina. Methods High-sensitivity C-reactive protein (hs-CRP), TG, TC, HDL-C and LDL-C were measured in selected UA patients and medical staff (control group) . UA patients were followed up for 3 months after discharge, stubborn angina pectoris, acute myocardial infarction and sudden cardiac death were observed. Results ① The levels of hs-CRP in unstable angina group were significantly higher than those in control group (P <0.05); ② There was a significant positive correlation between BMI, TC and hs-CRP; HDL-C was negatively correlated with hs-CRP; ③ The hs-CRP level in the end point of the cardiac event was higher than that in the non-cardiac event group (P <0.05). Conclusions The hs-CRP test in patients with unstable angina pectoris provides simple, economical and effective predictive measures for early-stage screening of patients at high risk and early intervention to reduce the incidence of cardiovascular events and mortality.