目的　了解小儿急性轮状病毒腹泻合并多系统器官感染的致病情况。方法　采用单克隆抗体酶联免疫吸附一步法 ,对 12 4例婴幼儿腹泻患儿进行大便及口咽分泌物轮状病毒抗原检测。结果　 12 4例婴幼儿腹泻中 ,合并呼吸道感染 38例 ,合并心肌损害 4例 ,中毒性脑病 4例 ,12 4例患儿大便轮状病毒抗原检测阳性率 96%,38例呼吸道感染患儿咽拭子检测阳性率 45 %。结论　轮状病毒可引起全身系统性感染 ,造成多器官功能损伤。 Objective To understand the pathogenesis of acute rotavirus diarrhea complicated with multiple system organ infections in children. Methods One hundred and fourteen cases of infantile diarrhea were tested for stool and oropharyngeal secretions of rotavirus by one-step monoclonal antibody enzyme-linked immunosorbent assay. Results In 12 4 cases of infantile diarrhea, there were 38 cases with respiratory tract infection, 4 cases with myocardial damage, 4 cases with toxic encephalopathy, 12 cases with 96% positive stool rotavirus antigen test and 38 cases with respiratory tract infection Swab test positive rate of 45%. Conclusion Rotavirus can cause systemic systemic infection, resulting in multiple organ damage.