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为探讨三氮唑核苷(病毒唑)剂量与给药途径对治疗呼吸道合胞病毒(RSV)感染疗效及病毒清除效应的影响,对54例RSV毛细支气管炎(毛支)患儿,分别用病毒唑常规剂量雾化吸入,加倍常规量雾化吸入,常规剂量静滴治疗.结果咳嗽、喘息、哮鸣音、湿罗音消失及RSV转阴时间、雾化吸入组明显短于静滴组(P<0.01),而退热时间长于静滴组(P<0.05).不同剂量雾化吸入时症状、体征改善及RSV转阴时间、无显著差异(P<0.05).说明病毒吐治疗毛支、雾化吸入疗效优于静滴,加大剂量雾化吸入,不能增加病毒清除效果及临床疗效.
To investigate the effect of ribavirin dose and route of administration on the therapeutic efficacy and virus clearance of respiratory syncytial virus (RSV) infection, 54 children with RSV bronchiolitis were treated with Routine doses of inhaled ribavirin inhaled, double the conventional inhalation dose, the conventional dose of intravenous infusion.Results Cough, wheezing, wheezing, wet rales disappeared and RSV negative time, aerosol inhalation group was significantly shorter than the intravenous infusion group (P <0.01), while the antipyretic time was longer than that of the intravenous drip group (P <0.05) .There was no significant difference in symptom, sign and RSV negative time (P <0.05) Support, atomization inhalation is better than intravenous infusion, increase the dose of inhalation, can not increase the effect of viral clearance and clinical efficacy.