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为了控制盐酸文拉法辛质量,分别合成了欧洲药典5.5版收载的6种有关物质:2-(4-甲氧基苯基)-N,N-二甲基乙胺(有关物质A)、1-[2-氨基-1-(4-甲氧基苯基)乙基]环已醇(有关物质C)、1-[1-(4-甲氧基苯基)-2-(甲胺基)-乙基]-环已醇(有关物质D)、5-(4-甲氧基苯基)-3-甲基-1-氧-3-氮杂螺[5.5]十一烷(有关物质E)、2-(1-环己烯基)-2-(4-甲氧基苯基)-N,N-二甲基乙胺(有关物质F)和2-环己基-2-(4-甲氧基苯基)-N,N-二甲基乙胺(有关物质G),并经1H NMR和MS确证结构。
In order to control the quality of Venlafaxine Hydrochloride, six related substances contained in the European Pharmacopoeia 5.5 edition were synthesized respectively: 2- (4-methoxyphenyl) -N, N-dimethylethanamine (related substance A) , 1- [2- amino-1- (4-methoxyphenyl) ethyl] cyclohexanol (related substance C), 1- [1- (4-methoxyphenyl) -2- Amino) -ethyl] -cyclohexanol (related substance D), 5- (4-methoxyphenyl) -3 -methyl- 1 -oxa-3-azaspiro [5.5] undecane Substance E), 2- (1-cyclohexenyl) -2- (4-methoxyphenyl) -N, N- dimethylethanamine (related substance F) and 2-cyclohexyl-2- (4-methoxyphenyl) -N, N-dimethylethanamine (related substance G) and confirmed by 1H NMR and MS.