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目的 :研究制首乌 (RadixPolygonimultifloriPreparata)化学成分。 方法 :应用硅胶、Sephadex、反相硅胶柱色谱对制首乌正丁醇萃取部分中化学成分进行分离纯化 ,应用理化常数测定和光谱 (IR ,MS ,1HNMR ,13 CNMR ,2D NMR)分析技术鉴定结构。结果 :分离并鉴定了 5个单体化合物 :大黄素甲醚 8 O β D 葡糖苷 (I)、大黄素 8 O β D 葡糖苷 (II)、决明蒽酮 8 O β D 葡糖苷 (III)、6 甲氧基 2 乙酰基 3 甲基 1,4 萘醌 8 O β D 葡糖苷 (IV)、2 ,3,5 ,4′ 四羟基二苯乙烯 2 O (2″ O 乙酰基 ) β D 葡糖苷 (V)。结论 :IV和V为新化合物。
Objective: To study the chemical composition of Radix Polygoni multiflori Prepara. METHODS: The chemical constituents of n-butanol extracted from Radix Polygoni multiflori were separated and purified by column chromatography on silica gel, Sephadex and reversed-phase silica gel. The physicochemical constants and spectroscopic (IR, MS, 1HNMR, 13 CNMR, 2D NMR) analysis were used to identify the chemical constituents. structure. Results: Five monomeric compounds were isolated and identified: emodin 8 O β D glucoside (I), emodin 8 O β D glucoside (II), californone 8 O β D glucoside (III ), 6 methoxy 2 acetyl 3 methyl 1,4 naphthoquinone 8 O β D glucoside (IV), 2,3,5,4′ tetrahydroxystilbene 2 O (2′′ O acetyl) β D Glucoside (V).Conclusion: IV and V are new compounds.