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目的探讨中药联合腹腔镜电切术治疗慢性宫颈炎对患者血清因子水平的影响。方法将200例慢性宫颈炎患者随机分为试验组和对照组各100例。2组患者均给予常规对症治疗、营养支持和密切护理。试验组给予中药联合腹腔镜电切术治疗慢性宫颈炎,对照组仅给予腹腔镜电切术治疗慢性宫颈炎。分别于治疗前、后抽取所有患者晨起空腹静脉血5ml,采用酶联免疫吸附试验检测并比较2组患者血清肿瘤坏死因子(TNF-α)、超氧化物歧化酶(SOD)、白介素-6(IL-6)及超敏C反应蛋白(hs-CRP)水平。结果治疗前2组患者血清TNF-α、SOD、IL-6、hs-CRP分子水平差异无统计学意义(P>0.05);治疗后,2组患者各项分子水平均明显降低,且试验组降低幅度大于对照组,差异均有统计学意义(P<0.05)。结论中药联合腹腔镜电切术治疗慢性宫颈炎可显著降低患者血清TNF-α、SOD、IL-6、hs-CRP分子水平。
Objective To investigate the effect of combined traditional Chinese medicine and laparoscopic electrosurgical treatment on serum factor levels in patients with chronic cervicitis. Methods 200 cases of chronic cervicitis were randomly divided into experimental group and control group of 100 cases. Both groups were given conventional symptomatic treatment, nutritional support and close care. The experimental group was treated with traditional Chinese medicine combined with laparoscopic resection of chronic cervicitis, the control group was given laparoscopic resection of chronic cervicitis. The fasting venous blood (5ml) was collected from all the patients before and after treatment. The levels of serum tumor necrosis factor (TNF), superoxide dismutase (SOD), interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) levels. Results There was no significant difference in the serum levels of TNF-α, SOD, IL-6 and hs-CRP between the two groups before treatment (P> 0.05). After treatment, the molecular levels of two groups were significantly decreased, The difference was statistically significant (P <0.05). Conclusion Chinese medicine combined with laparoscopic resection of chronic cervicitis can significantly reduce the level of serum TNF-α, SOD, IL-6, hs-CRP.