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为探讨增殖细胞核抗原(PCNA)与胃癌发生发展及预后的关系,采用SP免疫组化技术对99例胃癌组织中的PCNA进行测定。结果表明:胃癌组织PCNA标记指数显著高于异型增生胃粘膜(P<0.01);PCNA标记指数与胃癌淋巴结转移、淋巴管及血管侵犯、肿瘤浸润深度、肿瘤分期呈正相关(均P<0.05);PCNA标记指数<50％的患者术后1、3、5年生存率均显著高于PCNA标记指数≥50％者。提示检测PCNA标记指数可判断胃癌的侵袭转移潜能及患者的预后。
In order to investigate the relationship between proliferating cell nuclear antigen (PCNA) and the occurrence, development and prognosis of gastric cancer, SP immunohistochemical technique was used to detect PCNA in 99 cases of gastric cancer. The results showed that the PCNA labeling index of gastric cancer tissue was significantly higher than that of dysplastic gastric mucosa (P<0.01). The PCNA labeling index was positively correlated with lymph node metastasis, lymphatic vessel and vascular invasion, tumor invasion depth and tumor stage (all P<0.05). The survival rate at 1 year, 3 years and 5 years after PCNA labeling index <50% was significantly higher than that with PCNA labeling index ≥50%. Tip detection of PCNA marker index can determine the invasion and metastasis potential of gastric cancer and the prognosis of patients.