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目的 探讨同期应用小剂量顺铂能否提高局部晚期鼻咽癌放射治疗的效果。方法 对符合入组条件的 76例病例 ,随机分为放化疗组 (综合组 )和单独放疗组 (放疗组 )各 38例 ,两组放疗方法相同 ,综合组于放疗同时给予小剂量顺铂静滴化疗。结果 治疗结束时 ,综合组和放疗组鼻咽肿瘤全消率分别为 81 .58%和 6 3.1 6 %(P <0 .0 5) ,颈淋巴结全消率分别为 84 .2 1 %和 6 0 .52 % ,综合组局部肿瘤消退放疗剂量明显低于放疗组 (P <0 .0 5)两组毒付反应相近 (P >0 .0 5)均可耐受。结论 局部晚期鼻咽癌放疗辅以小剂量顺铂治疗能促进晚期鼻咽癌原发灶及颈淋巴结消退 ,提高局部控制率 ,急性毒副作用能耐受
Objective To investigate whether simultaneous application of low-dose cisplatin can improve the efficacy of radiotherapy for locally advanced nasopharyngeal carcinoma. Methods A total of 76 patients were enrolled and divided into radiotherapy and chemotherapy group (combination group) and radiotherapy alone group (radiotherapy group), 38 cases in each group. The radiotherapy method was the same in both groups. Radiotherapy combined with low dose cisplatin Drop of chemotherapy. Results At the end of treatment, the total elimination rates of nasopharyngeal tumors in the combination group and the radiotherapy group were 81.58% and 61.6% respectively (P0.05), and the total elimination rates of cervical lymph nodes were 84.21% and 6 0.52%. The dose of local tumor regression radiotherapy in the integrated group was significantly lower than that in the radiotherapy group (P <0. 05). Both groups were tolerant (P 0. 05). Conclusion Radiotherapy combined with low-dose cisplatin in locally advanced nasopharyngeal carcinoma can promote the regression of primary nasopharyngeal carcinoma and cervical lymph nodes, improve the local control rate and acute toxicities and side effects