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1987年在澳大利亚悉尼召开的第十届国际药理学大会上,较多学者报告了突触后膜(包括中枢和外周)上也存在相应的a_2受体,其功能不仅限于对递质的负反馈调节,也可能包括对心血管活动、交感张力以及肾上腺儿茶酚胺释放等的影响。本文仅就这方面的内容作一简介。 肾上腺素a_2受体对心血管活动的影响 自发现突触后膜上存在a_2受体以后,对其参与心血管活动的功能有了较新的认识。丹麦Nielson等采用微血管肌动描记仪,在体外研究了人类阻力小动脉(直径为100～160μM)上a_2受体的作用,所用标本主要来自外科手术时从皮下脂肪中分离出的血管。15个病人的20根小血管在a_1受体拮抗剂喹恶哌嗪存在下,对a_2受体激动剂BHT933呈剂量依赖性的收缩,
At the Tenth International Congress of Pharmacology held in Sydney, Australia in 1987, more scholars reported that the corresponding a_2 receptors also exist on the postsynaptic membrane (including the central and peripheral), and its function is not limited to negative feedback on neurotransmitters Regulatory effects may also include effects on cardiovascular activity, sympathetic tone, and adrenal catecholamine release. This article only on the content of a brief introduction. Effects of Adrenergic Angiotensin-2 Receptor on Cardiovascular Activity Since the discovery of a_2 receptors on the postsynaptic membrane, a new understanding of its role in cardiovascular activity has emerged. In Denmark, Nielson et al. Used microvascular angiographs to study the effects of a_2 receptors on human resistance arterioles (100-160 μM in diameter) in vitro using primarily blood vessels isolated from subcutaneous fat during surgery. 20 small blood vessels of 15 patients in a dose-dependent contraction of the a2 receptor agonist BHT933 in the presence of the a 1 receptor antagonist quinopiprazin,