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目的:了解潜艇艇员长航前后免疫功能状况,为长航后休养干预方案提供依据。方法:对潜艇艇员82名长航(30天)前后免疫因子抽取血样检测,比较长航前后免疫指标变化。结果:与长航前比较,长航后艇员血清免疫指标中可溶性IL-2R非常显著升高(P<0.01),补体C3、补体C4、IgG显著或非常显著下降(P<0.05,P<0.01);IL-2R、IL-1、补体C3、补体C4、IgG阳性率均较长航前非常显著增高(P<0.01)。结论:潜艇艇员长航后血清免疫因子指标较长航前有显著变化,提示长航对免疫功能有一定影响,应采取适当的康复干预措施。
Objective: To understand the immune function of submarine crew before and after long-term flight, and provide the basis for the recuperation plan after long-flight. Methods: Blood samples were taken from 82 long-haul (30 days) submarine crew before and after immunization, and the changes of immune indexes before and after long-haul were compared. Results: Compared with that before long flight, the levels of soluble IL-2R were significantly increased (P <0.01) and the levels of complement C3, complement C4 and IgG were significantly decreased (P <0.05, P < 0.01). The positive rates of IL-2R, IL-1, complement C3, complement C4 and IgG were significantly higher than those before long voyage (P <0.01). CONCLUSIONS: The long-term submarine long-haul serum immune factors index significant changes before long flight, suggesting that long flights have some impact on immune function, appropriate rehabilitation interventions should be taken.