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目的探讨比较不同质子泵抑制剂奥美拉唑与泮托拉唑治疗消化性溃疡出血的临床疗效及安全性。方法选取2014年1月至2015年1月广东省河源市龙川县妇幼保健院收治的消化性溃疡出血患者100例作为研究对象。所有患者对本研究完全知情同意,均确诊为消化性溃疡出血,采用随机数表法将其分为A组与B组,每组50例,其中A组选用奥美拉唑治疗,B组患者采用泮托拉唑治疗,比较两组患者治疗7 d后的临床疗效及并发症发生情况。结果 B组患者治疗后显效24例,有效23例,总有效率为94.0%,A组治疗后显效17例,有效21例,总有效率为76.0%,B组患者治疗总有效率明显高于A组,差异有统计学意义(P<0.05);B组患者的平均停止出血时间明显短于A组,且第1、3天出血量明显低于A组(P<0.05);两组患者恶心、腹泻、皮疹等不良反应发生率比较差异无统计学意义(P>0.05)。结论质子泵抑制剂奥美拉唑与泮托拉唑均可用于治疗消化性溃疡出血,但泮托拉唑疗效较奥美拉唑具有一定的优越性,并且安全性较高。
Objective To compare the clinical efficacy and safety of different proton pump inhibitors omeprazole and pantoprazole in the treatment of peptic ulcer bleeding. Methods From January 2014 to January 2015, 100 cases of peptic ulcer bleeding in Longchuan County Maternal and Child Health Hospital of Heyuan City, Guangdong Province were selected as the research object. All patients were completely informed consent of this study, were diagnosed as peptic ulcer bleeding, using random number table method will be divided into group A and group B, 50 cases in each group, of which group A was treated with omeprazole, group B patients Pantoprazole treatment, the two groups of patients after 7 days of treatment of clinical efficacy and complications. Results In group B, 24 cases were markedly effective, 23 cases were effective, 94.0% were effective, 17 cases were effective in group A, 21 cases were effective and the total effective rate was 76.0%. The total effective rate in group B was significantly higher than that in group B Group A, the difference was statistically significant (P <0.05); Group B patients were significantly shorter than the average stop bleeding time, and the first and third days bleeding was significantly lower than the A group (P <0.05); two groups of patients Nausea, diarrhea, rash and other adverse reactions was no significant difference (P> 0.05). Conclusion Both proton pump inhibitors omeprazole and pantoprazole can be used for the treatment of peptic ulcer bleeding, but pantoprazole has some advantages over omeprazole and has higher safety.