论文部分内容阅读
卵巢肿瘤是女性生殖系统最常见的恶性疾病,而且多数患者就诊时都已处于疾病的中晚期。因此临床上迫切需要找到一些更具敏感性及准确性的诊断方法,包括一些肿瘤标记物。关于激活素(activin)和抑制素(inhibin)生化性质等的研究日益成熟。两者与卵巢肿瘤的关系成为研究热点。激活素和抑制素同属于转化生长因子β(TGF-β)超家族成员,都是由性腺分泌的细胞因子。已发现,激活素和抑制素具有调节垂体分泌卵泡刺激素(FSH)的功能。激活素是β亚基的异二聚体,而α和βA亚基构成抑制素A(αβA),α和βB组成抑制素B(αβB)。综述激活素和抑制素对卵巢肿瘤的作用。
Ovarian cancer is the most common malignant disease of the female reproductive system, and most patients are already in the mid to late stages of their illness at the time of their visit. Therefore, there is an urgent need to find some clinically more sensitive and accurate diagnostic methods, including some tumor markers. Research on the biochemical properties of activin and inhibin has become increasingly mature. The relationship between the two and ovarian cancer has become a research hot spot. Activin and inhibin, both members of the transforming growth factor beta (TGF-beta) superfamily, are cytokines secreted by the gonads. Activin and inhibin have been found to regulate pituitary follicle stimulating hormone (FSH) function. Activin is a heterodimer of the β subunit, while the α and βA subunits comprise inhibin A (αβA) and α and βB consist of inhibin B (αβB). The effects of activin and inhibin on ovarian tumors are reviewed.