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目的了解聊城市手足口病重症病例的流行病学特征及影响因素。方法对2009年、2010年聊城市手足口病重症病例进行流行病学分析,并对部分轻症和重症病例进行问卷调查,采用非条件Logistic回归分析方法对相关资料进行分析,以获得重症病例发病的影响因素。结果同一年份不同地区重症发生率之间存在统计学差异,2009年98.91%的重症病例年龄≤5岁,2010年为99.56%。多因素非条件Logistic回归分析显示,年龄的增长是手足口病重症发病的保护因素,而就医延迟、出现发热、出现皮疹是危险因素。2009～2010年合计检测手足口病重症病例粪便标本105份,其中肠道病毒核酸阳性71份,阳性率为67.62%。阳性者中,EV71型51例,占71.83%,CoxA16型3例,占0.23%,其他肠道病毒17例,占23.94%。结论聊城市手足口病重症发生率较高,主要流行毒株为EV71型。对于年龄较小、就医延迟、出现发热、皮疹的患儿要更加重视,以防其发展为重症病例。
Objective To understand the epidemiological characteristics and influencing factors of HFMD in Liaocheng city. Methods The epidemiological analysis of severe cases of hand-foot-mouth disease in Liaocheng in 2009 and 2010 was conducted. Questionnaire investigation was carried out on some cases of mild and severe cases. Non-conditional Logistic regression analysis was used to analyze the relevant data to obtain the incidence of severe cases The impact of factors. Results There was a significant difference in the incidence of severe diseases in different regions in the same year. In 2009, 98.91% of the severe cases were ≤5 years old and 99.56% in 2010. Multivariate non-conditional logistic regression analysis showed that age was the protective factor of HFMD. Delay of medical treatment, fever and rash appeared to be risk factors. From 2009 to 2010, a total of 105 stool samples of HFMD were detected, of which 71 were positive for enterovirus nucleic acid, the positive rate was 67.62%. Among the positive cases, 51 cases (71.83%) were EV71, 3 cases were CoxA16 (0.23%), and 17 cases were other enteroviruses (23.94%). Conclusion The incidence of HFMD in Liaocheng City is high, and the major epidemic strain is EV71. For younger children, medical treatment delays, fever, rash children should pay more attention to prevent the development of severe cases.