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目的:探讨甘露醇治疗脑出血引起肾损伤的临床特点及防治方法。方法:回顾2008年6月～2012年6月间对90例脑血管病患者用甘露醇作为渗透脱水剂降低颅内压、改善脑水肿及清除自由基时,40例出现肾功能损害进行回顾性研究。结果:甘露醇在治疗脑血管病中有的患者出现急性肾损伤。结论:用甘露醇治疗脑血管病会造成急性肾功能衰竭,甘露醇可引起与剂量有关的可逆性肾损害,需控制使用剂量、改进肾功能监测方法、及时纠正其他肾损伤因素,以尽早预防并予以及时治疗。停药后大部分患者肾功能可以恢复正常。
Objective: To investigate the clinical characteristics and prevention and treatment of mannitol in treating renal injury caused by cerebral hemorrhage. Methods: A retrospective review of 90 cases of cerebrovascular disease patients with mannitol as a permeable dehydrant to reduce intracranial pressure, improve cerebral edema and free radical scavenging from June 2008 to June 2012 were reviewed retrospectively the study. Results: Acute kidney injury occurred in some patients with mannitol in the treatment of cerebrovascular disease. Conclusion: Mannitol treatment of cerebrovascular disease can cause acute renal failure, mannitol can cause dose-related reversible renal damage, need to control the use of dose, improve renal function monitoring methods, and timely correction of other renal injury factors in order to prevent as soon as possible And be treated promptly. After stopping the majority of patients with renal function can return to normal.