一篇发表在联合王国的文章讨论了与非肠道应用抗生素——尤其β-内酰胺类如青霉素、头孢菌素类有关的潜在性危险。文章指出,这类化合物经常以大剂量给药,而且一般用的是抗生素钠盐。因而相当大量的钠可能被患者无意识地摄入。例如青霉素G钠注射给药时推荐的最大日剂量为20g,该剂量每天将提供56mmol钠的负荷理。作者指出大剂量抗生素在多数情况下是适合的,然而在摄入钠时,例如肝病患者尤其是有腹水者治疗时应加以调节和限制。作者结论说,“当静注某些抗生素制剂时应注意因钠过量所致的危险性。在实际应用很大剂量抗 An article published in the United Kingdom discusses the potential dangers associated with parenteral antibiotics - especially beta-lactams such as penicillins and cephalosporins. The article states that such compounds are often administered in high doses, and antibiotic sodium salts are commonly used. Thus a considerable amount of sodium may be unconsciously taken by the patient. For example, the maximum daily dose recommended for sodium injection of penicillin G is 20 g, which will provide 56 mmol of sodium daily. The authors point out that high doses of antibiotics are suitable in most cases, but should be adjusted and limited when sodium is ingested, for example in patients with liver disease, especially with ascites. The authors conclude that "the risk of overdosing of sodium should be noted when intravenous infusion of certain antibiotic agents. In practice, very high doses of anti-