骨肉瘤好发于青少年,80%以上的病例,肿瘤位于膝关节附近。传统的早期高位截肢,给病人带来严重残废;且多在半年到一年之间,发生肺转移而死亡。自1970年以来,由于化疗的进展,减少了肺转移的发生,五年存活率由原来的20%左右提高到50%以上,甚而达80%左右。因此,为减少残废,在化疗辅助下,采取保存患肢的手术治疗已成当前的重大课题。 Osteosarcoma occurs predominantly in adolescents, with more than 80% of cases. The tumor is located near the knee joint. The traditional early high amputation caused serious disability to the patient; moreover, it took more than half a year to a year to have died of lung metastasis. Since 1970, due to the progress of chemotherapy, the incidence of lung metastasis has been reduced, and the five-year survival rate has increased from about 20% to more than 50%, and even to about 80%. Therefore, in order to reduce the disability, the surgical treatment of preservation of the affected limb has become a major issue under the assistance of chemotherapy.