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目的探讨前列腺素E2(PGE2)对阻塞性黄疸大鼠小肠粘膜的保护作用。方法Wistar大鼠50只,随机分成阻塞性黄疸组(A组)10只、阻塞性黄疸再通组(B组)10只、阻塞性黄疸PGE2干预组(C组)10只、阻塞性黄疸再通加PGE2干预组(D组)10只和假手术组(E组)10只。采用直接结扎法制成阻塞性黄疸大鼠模型。再通组采用导管法再通。结扎后1周给予PGE2,结扎后2周再通,再通手术后1周取标本,观察大鼠小肠粘膜的形态学变化。结果PGE2干预组小肠粘膜损伤评分为(2.21±0.75),手术再通组大鼠小肠损伤评分为(2.05±0.71),均较黄疸组减轻(5.26±0.57,P<0.05)。结论阻塞性黄疸大鼠小肠粘膜明显受损,PGE2及手术再通均可减少其损伤。但两者没有协同作用。
Objective To investigate the protective effect of prostaglandin E2 (PGE2) on small intestinal mucosa in obstructive jaundice rats. Methods Fifty Wistar rats were randomly divided into obstructive jaundice group (A group), obstructive jaundice recanalization group (B group), obstructive jaundice PGE 2 intervention group (C group), obstructive jaundice Tong PGE2 intervention group (D group) 10 and sham operation group (E group) 10. Obstructive jaundice rat model was made by direct ligation. Recanalization group using catheter recanalization. One week after the ligation, PGE2 was given. Two weeks after the ligation, the animals were sacrificed and the specimens were taken one week after the operation. Morphological changes of small intestinal mucosa were observed. Results The score of intestinal mucosa injury in PGE2 -treated group was (2.21 ± 0.75), and that in surgery-re-treated group was (2.05 ± 0.71), which was significantly lower than that in jaundice group (5.26 ± 0.57, P <0.05). Conclusion Obstructive jaundice rat intestinal mucosa was significantly impaired, PGE2 and surgery recanalization can reduce its damage. But there is no synergy between the two.