皮革胃又称弥漫浸润型胃癌或 BorrmannⅣ胃癌,是指癌组织沿粘膜下层、肌层、浆膜层弥漫性浸润生长,胃壁广泛增厚、变硬,而呈皮革状,故称皮革胃。此型胃癌恶性度高,发生淋巴结转移早,术后存活率低。因粘膜层未受累,胃镜下缺乏粘膜征象的特征性改变,加之常规粘膜活检阴性率高 Leather stomach, also known as diffuse infiltration of gastric cancer or BorrmannⅣ gastric cancer, refers to cancer tissue along the submucosa, myometrial, serosa diffuse infiltration of growth, extensive thickening of the stomach wall, hardened, and was leathery, so called leather stomach. This type of gastric cancer is highly malignant, lymph node metastasis occurs early, postoperative survival rate is low. Due to the mucosal layer is not involved, the lack of endoscopic mucosal signs of the characteristic changes, combined with conventional mucosal biopsy negative rate