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目的通过测定不稳定型心绞痛(UAP)患者心绞痛入院时血清尿酸(UA)水平,并与稳定型心绞痛(SAP)患者及健康者比较,探讨尿酸与心绞痛发作之间的关系。方法测定219例于本院诊断为“不稳定型心绞痛”患者入院时的高敏C反应蛋白(hs-CRP)和UA水平。在门诊体检者中选取稳定型心绞痛(SAP)患者75例和健康对照组87例。结果各组间UA水平:UAP组(357±63)μmol/L,SAP组(259±42)μmol/L,健康对照组(207±35)μmol/L。UAP组与SAP组及健康对照组比较差异均有统计学意义(P均<0.05)。结论血清尿酸与不稳定型心绞痛的发生有一定的关系,故检测不稳定型心绞痛患者的尿酸水平,有助于了解和评价病情,早期干预可能会减少心血管事件的发生。
Objective To investigate the relationship between serum uric acid (UA) and angina pectoris in patients with unstable angina pectoris (UAP) at admission and to compare with patients with stable angina pectoris (SAP) and healthy subjects. Methods 219 cases of high-sensitivity C-reactive protein (hs-CRP) and UA in patients with “unstable angina pectoris” admitted to our hospital were determined. 75 outpatients with stable angina pectoris (SAP) and 87 healthy controls were enrolled in this study. Results The levels of UA in each group were 357 ± 63 μmol / L in UAP group, 259 ± 42 μmol / L in SAP group and 207 ± 35 μmol / L in healthy control group. There was significant difference between UAP group and SAP group and healthy control group (all P <0.05). Conclusions Serum uric acid is associated with the occurrence of unstable angina pectoris. Therefore, the uric acid level in patients with unstable angina pectoris is helpful to understand and evaluate the condition. Early intervention may reduce the occurrence of cardiovascular events.