论文部分内容阅读
近年来发现三氧化二砷(arsenictrioxide,As2O3)对白血病的治疗很有效,尤其是对急性早幼粒白血病的治疗更有效。As2O3的作用机制不很清楚,但体外及体内实验均已证明诱导细胞分化或促进细胞凋亡是其发挥疗效的两种主要方式[1]。已有的研究表明,As2O3诱导细胞凋亡可能和一些常见的
In recent years, it has been found that arsenictrioxide (As2O3) is very effective in the treatment of leukemia and especially in the treatment of acute promyelocytic leukemia. The mechanism of action of As2O3 is unclear, but both in vitro and in vivo experiments have demonstrated that induction of cell differentiation or promotion of apoptosis is the two main ways in which it exerts its effects [1]. Some studies have shown that As2O3 induced apoptosis may be some common