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目的 探讨血清糖链抗原２４２（ＣＡ２４２）、神经元特异性烯酸化酶（ＮＳＥ）及癌胚抗原（ＣＥＡ）等 ３项指标联合检测 对肺癌的诊断价值。方法采用酶联免疫法。结果肺癌组（ｎ＝８７）３项指标均明显高于结核组（ｎ＝３０）（Ｐ＜０．０１）。以健康对 照组（ｘ＋２ｓ）值为肺癌诊断的临界值（ＣＡ２４２为 ２０Ｕ／ｍｌ，ＮＳＥ为 ２０ｕ ｇ／１，ＣＥＡ为 ５ｎｇ／ｍｌ），则 ＣＡ２４２对肺腺癌（ＡＣ），鳞癌 （Ｓｑ）及小细胞肺癌（ＳＣＬＣ）的敏感性分别为 ６５．６％、４２．８％及 ３３．３％，特异性均为 ９３．８％。ＮＳＥ的敏感性分别为 ３１．３％、４２．８％ 及７０．４％，特异性均为９５．２％。ＣＥＡ的敏感性分别为７５．０％、５３．５％及５５．６％，特异性均为９５．２％。３项指标中，如以１项阳性作 为肺癌的诊断依据，则 ＡＣ、Ｓｑ、ＳＣＬＣ的阳性率可分别达 ９６．９％、９２．９％及 ９２．６％；如选择两项阳性作为诊断依据，则阳性率可达 ７８．１％、５３．５％及６６．７％，而结核组和正常组的假阳性率仅为６．６７％及０．０％；如以３项阳性作为诊断依据，则阳性率分别为 ４０．６％，３９．３％及 ４４．４％，而对照组无１例阳性。结论 ３项指标对不同组?
Objective To investigate the diagnostic value of combined detection of three markers of serum carbohydrate antigen 242 (CA242), neuron specific enolase (NSE) and carcinoembryonic antigen (CEA) in lung cancer. Methods Using enzyme-linked immunosorbent assay. Results Lung cancer (n = 87) were significantly higher than those in the nodules (n = 30) (P <0.01). The value of x + 2s for the diagnosis of lung cancer (CA242 20U / ml, NSE 20u g / 1, CEA 5ng / ml) And small cell lung cancer (SCLC) were 65.6%, 42.8% and 33.3%, respectively, with a specificity of 93.8%. The sensitivity of NSE was 31.3%, 42.8% and 70.4% respectively, and the specificity was 95.2%. The sensitivity of CEA was 75.0%, 53.5% and 55.6% respectively, and the specificity was 95.2%. Among the three indexes, if one positive was used as the diagnosis basis of lung cancer, the positive rates of AC, Sq and SCLC could reach 96.9%, 92.9% and 92.6% respectively; if two positives were selected as the diagnosis According to the results, the positive rates could reach 78.1%, 53.5% and 66.7%, while the false positive rates of tuberculosis group and normal group were only 6.67% and 0.0% According to the diagnosis, the positive rates were 40.6%, 39.3% and 44.4% respectively, but none in the control group. Conclusion 3 indicators of different groups?